Endocrine Abstracts

Introduction: Increased adrenal androgen production is present in 20–60% of women with polycistic ovary syndrome (PCOS). Possible mechanism is not clarified yet and could be related to altered hypothalamic-pituitary-adrenal-axis (HPA) activity or a consequence of adrencortical steroidogenic abnormalities. The aim of the study was to assess HPA sensitivity in PCOS women using different doses of dexamethasone.Methods: We analyzed 359 women with PCOS d...

Introduction: Recently, it was suggested that insulin resistance index using C-peptide (CIR) could be a better marker of insulin resistance than homeostasis model assessment (HOMA-IR) in patients with type 2 diabetes mellitus. The aim of this study was to investigate performance of CIR index in PCOS subjects.Methods: We evaluated 187 PCOS women (PCOS: 25.38±6.32 kg/m2; 26.01±5.16 years) diagnosed using ESHRE/ASRM criteria and 42 heal...

Introduction: It has been shown that subjects with normal fasting glucose (NFG) and normal glucose tolerance (NGT), whose plasma glucose concentration does not return to their fasting plasma glucose (FPG) level within 2 h following standard oral glucose tolerance test (OGTT), have higher risk of progression into type 2 diabetes (T2D) than NFG/NGT subjects whose glucose returns to FPG level after OGTT. Although the development of T2D during the life of woman with polycystic ova...

Introduction: Polycystic ovary syndrome (PCOS) phenotypes A and B are considered to be more hyperandrogenic in comparison to phenotypes C and D that are considered to be mostly reproductive. The aim of this study was to analyze distribution of androgens in different phenotypes in our PCOS population.Methods: We evaluated 365 PCOS women (PCOS:25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 healthy women...

Introduction: Insulin resistance (IR) is a well recognised feature in women with polycystic ovary syndrome (PCOS). The aim of this study was to analyse IR indices obtained from oral glucose tolerance test (OGTT), in different PCOS phenotypes.Methods: We evaluated 240 PCOS women (PCOS: 24.86±5.97 kg/m2; 25.25±4.98 years) diagnosed using ESHRE/ASRM criteria and 70 BMI-matched healthy women (controls: 26.14±4.86 kg/m2; 3...

Introduction: Although phenotype D is well recognised in clinical studies about PCOS, there is still a debate if this phenotype should be evaluated as part of PCOS spectrum. The aim of this study was to evaluate usual anthropometric characteristics in PCOS phenotypes.Methodology: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (Controls: 25.4...

Introduction: Women with PCOS have increased risk for non-alcoholic fatty liver disease (NAFLD). Alanine aminotransferase (ALT) is a sensitive indicator of liver cell injury. The aim of this study is to determine levels of liver enzymes in normal-weight women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Normal weight was defined as BMI ≤25 kg/m2. We evaluated 62 normal weight women with PCOS (PCOS group: 20.99±1....

Introduction: Women with polycystic ovary syndrome (PCOS) have higher prevalence of metabolic syndrome (MS) than healthy women. However, it is still unclear weather this is a consequence of PCOS per se or higher prevalence of obesity in this population. The aim of this study was to determine prevalence of MS in obese women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. Obesity was defined as BMI ≥25 kg/m2. We e...

Background: Insulin secretory defects and insulin resistance exists in women with polycystic ovary syndrome (PCOS) and are prerequisites for the development of type 2 diabetes (T2D). we aimed to determine the prevalence of T2D, impaired glucose tolerance (IGT) and impaired fasting glucose (IFG), as well as the factors associated with these dysglycemic conditions in this population.Methods: 1614 PCOS women of Caucasian origin (Rotterdam criteria) with a m...

Introduction: It has been shown that most women with polycystic ovary syndrome (PCOS) have increased adrenal androgen production, enhanced peripheral metabolism of cortisol and elevated in urinary excretion of its metabolites. Simultaneously, this increased cortisol clearance in PCOS was shown to be followed by a compensatory overdrive of the hypothalamo–pituitary–adrenal (HPA) axis. The aim of this study was to determine HPA axis sensitivity in women woth PCOS.<...